NFL Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component:  axon; axon cytoplasm; cholinergic synapse; cytoplasm; cytosol; growth cone; neurofilament; neuromuscular junction; postsynaptic intermediate filament cytoskeleton; presynaptic intermediate filament cytoskeleton; Schaffer collateral - CA1 synapse
Molecular Function:  identical protein binding; phospholipase binding; protein binding; protein binding, bridging; protein C-terminus binding; protein domain specific binding; protein heterodimerization activity; structural constituent of cytoskeleton; structural constituent of postsynaptic intermediate filament cytoskeleton
Biological Process:  anterograde axonal transport; axonal transport of mitochondrion; cerebral cortex development; hippocampus development; intermediate filament organization; intermediate filament polymerization or depolymerization; locomotion; MAPK cascade; microtubule cytoskeleton organization; negative regulation of neuron apoptotic process; neurofilament bundle assembly; neurofilament cytoskeleton organization; neuromuscular process controlling balance; neuron projection morphogenesis; peripheral nervous system axon regeneration; positive regulation of axonogenesis; postsynaptic intermediate filament cytoskeleton organization; protein polymerization; regulation of axon diameter; regulation of NMDA receptor activity; response to acrylamide; response to corticosterone; response to peptide hormone; response to sodium arsenite; retrograde axonal transport; spinal cord development; synapse maturation
Disease: Charcot-marie-tooth Disease, Axonal, Type 2e; Charcot-marie-tooth Disease, Demyelinating, Type 1f; Charcot-marie-tooth Disease, Dominant Intermediate G
Reference #:  P07196 (UniProtKB)
Alt. Names/Synonyms: 68 kDa neurofilament protein; CMT1F; CMT2E; FLJ53642; light molecular weight neurofilament protein; NEFL; Neurofilament light polypeptide; neurofilament protein, light chain; neurofilament subunit NF-L; Neurofilament triplet L protein; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament-light; NF-L; NF68; NFL
Gene Symbols: NEFL
Molecular weight: 61,517 Da
Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB