IL16
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation. 4 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cytokine; DNA-binding; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 15q25.1 |
Cellular Component:
cytosol; extracellular region; extracellular space; Flemming body; focal adhesion; nuclear speck; plasma membrane
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Molecular Function:
CD4 receptor binding; cytokine activity
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Biological Process:
immune response; induction of positive chemotaxis; leukocyte chemotaxis; positive regulation of inflammatory response; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; regulation of calcium ion transport; signal transduction
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Reference #:
Q14005
(UniProtKB)
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Alt. Names/Synonyms: FLJ16806; FLJ42735; FLJ44234; IL-16; IL16; interleukin 16; interleukin 16 (lymphocyte chemoattractant factor); Interleukin-16; LCF; Lymphocyte chemoattractant factor; neuronal interleukin 16; NIL16; prIL-16; PRIL16; Pro-interleukin-16; prointerleukin 16
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Gene Symbols: IL16
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Molecular weight:
141,752 Da
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Basal Isoelectric point:
8.34
Predict pI for various phosphorylation states
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