IL16 Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. 3 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Cytokine; DNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q25.1
Cellular Component:  cytosol; extracellular region; extracellular space; nuclear speck; plasma membrane
Molecular Function:  CD4 receptor binding; cytokine activity
Biological Process:  cytokine-mediated signaling pathway; immune response; induction of positive chemotaxis; leukocyte chemotaxis; regulation of calcium ion transport; regulation of signaling receptor activity; viral process
Reference #:  Q14005 (UniProtKB)
Alt. Names/Synonyms: FLJ16806; FLJ42735; FLJ44234; IL-16; IL16; interleukin 16 (lymphocyte chemoattractant factor); Interleukin-16; LCF; Lymphocyte chemoattractant factor; neuronal interleukin 16; NIL16; prIL-16; PRIL16; Pro-interleukin-16; prointerleukin 16
Gene Symbols: IL16
Molecular weight: 141,752 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene