IL16 Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation. 4 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytokine; DNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 15q25.1
Cellular Component:  cytosol; extracellular region; extracellular space; Flemming body; focal adhesion; nuclear speck; plasma membrane
Molecular Function:  CD4 receptor binding; cytokine activity
Biological Process:  immune response; induction of positive chemotaxis; leukocyte chemotaxis; positive regulation of inflammatory response; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; regulation of calcium ion transport; signal transduction
Reference #:  Q14005 (UniProtKB)
Alt. Names/Synonyms: FLJ16806; FLJ42735; FLJ44234; IL-16; IL16; interleukin 16; interleukin 16 (lymphocyte chemoattractant factor); Interleukin-16; LCF; Lymphocyte chemoattractant factor; neuronal interleukin 16; NIL16; prIL-16; PRIL16; Pro-interleukin-16; prointerleukin 16
Gene Symbols: IL16
Molecular weight: 141,752 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein