LTA4H Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. Belongs to the peptidase M1 family. Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.3.2.6; Hydrolase; Lipid Metabolism - arachidonic acid
Chromosomal Location of human Ortholog: 12q23.1
Cellular Component:  cytosol; extracellular region; ficolin-1-rich granule lumen; nucleoplasm; nucleus; tertiary granule lumen
Molecular Function:  aminopeptidase activity; epoxide hydrolase activity; leukotriene-A4 hydrolase activity; metalloaminopeptidase activity; peptidase activity; protein binding; zinc ion binding
Biological Process:  cellular protein metabolic process; leukotriene biosynthetic process; leukotriene metabolic process; long-chain fatty acid biosynthetic process; neutrophil degranulation; peptide catabolic process; proteolysis
Reference #:  P09960 (UniProtKB)
Alt. Names/Synonyms: Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase; leukotriene A4 hydrolase; LKHA4; LTA-4 hydrolase; LTA4; LTA4H; testicular secretory protein Li 27
Gene Symbols: LTA4H
Molecular weight: 69,285 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
Select Structure to View Below

LTA4H

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene