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P2X2
Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. Belongs to the P2X receptor family. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 12q24.33 |
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Cellular Component:
apical plasma membrane; neuronal cell body; neuronal dense core vesicle; plasma membrane; postsynapse; receptor complex
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Molecular Function:
ATP binding; extracellularly ATP-gated monoatomic cation channel activity; identical protein binding; ligand-gated monoatomic ion channel activity; purinergic nucleotide receptor activity
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Biological Process:
behavioral response to pain; calcium ion transmembrane transport; detection of hypoxic conditions in blood by carotid body chemoreceptor signaling; excitatory postsynaptic potential; monoatomic cation transmembrane transport; neuromuscular junction development; neuromuscular synaptic transmission; peristalsis; positive regulation of calcium ion transport into cytosol; positive regulation of calcium-mediated signaling; purinergic nucleotide receptor signaling pathway; response to ATP; response to carbohydrate; response to hypoxia; response to ischemia; sensory perception of sound; sensory perception of taste; skeletal muscle fiber development; urinary bladder smooth muscle contraction
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Disease: Deafness, Autosomal Dominant 41
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Reference #:
Q9UBL9
(UniProtKB)
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Alt. Names/Synonyms: ATP receptor; DFNA41; MGC129601; P2RX2; P2X purinoceptor 2; P2X Receptor, subunit 2; P2X2; Purinergic receptor; purinergic receptor P2X 2; purinergic receptor P2X, ligand gated ion channel, 2; purinergic receptor P2X, ligand-gated ion channel, 2
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Gene Symbols: P2RX2
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Molecular weight:
51,754 Da
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Basal Isoelectric point:
8.4
Predict pI for various phosphorylation states
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