ICAM3 ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages. Belongs to the immunoglobulin superfamily. ICAM family. Leukocytes. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of human Ortholog: 19p13.2
Cellular Component:  plasma membrane
Molecular Function:  integrin binding; protein binding; signaling receptor binding
Biological Process:  cell adhesion; cell-cell adhesion; phagocytosis
Reference #:  P32942 (UniProtKB)
Alt. Names/Synonyms: CD50; CDw50; ICAM-3; ICAM-R; ICAM3; Intercellular adhesion molecule 3; intercellular adhesion molecule-3
Gene Symbols: ICAM3
Molecular weight: 59,541 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein