BAX Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. Belongs to the Bcl-2 family. Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor
Chromosomal Location of human Ortholog: 19q13.33
Cellular Component:  BAK complex; BAX complex; Bcl-2 family protein complex; cell periphery; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; mitochondrial outer membrane; mitochondrial permeability transition pore complex; mitochondrion; nuclear envelope; nucleus; pore complex
Molecular Function:  BH3 domain binding; channel activity; chaperone binding; Hsp70 protein binding; identical protein binding; lipid binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; apoptotic mitochondrial changes; apoptotic process; apoptotic process involved in blood vessel morphogenesis; apoptotic process involved in embryonic digit morphogenesis; apoptotic process involved in mammary gland involution; apoptotic signaling pathway; B cell apoptotic process; B cell homeostasis; B cell homeostatic proliferation; B cell negative selection; B cell receptor apoptotic signaling pathway; blood vessel remodeling; calcium ion transport into cytosol; cellular response to unfolded protein; cellular response to UV; cellular response to virus; cerebral cortex development; development of secondary sexual characteristics; ectopic germ cell programmed cell death; endoplasmic reticulum calcium ion homeostasis; epithelial cell apoptotic process; establishment or maintenance of transmembrane electrochemical gradient; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; fertilization; germ cell development; glycosphingolipid metabolic process; homeostasis of number of cells within a tissue; hypothalamus development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; kidney development; mitochondrial fragmentation involved in apoptotic process; mitochondrial fusion; mitochondrion morphogenesis; motor neuron apoptotic process; myeloid cell homeostasis; negative regulation of apoptotic signaling pathway; negative regulation of endoplasmic reticulum calcium ion concentration; negative regulation of fibroblast proliferation; negative regulation of mitochondrial membrane potential; negative regulation of neuron apoptotic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein binding; neuron migration; odontogenesis of dentin-containing tooth; ovarian follicle development; peptidyl-serine phosphorylation; positive regulation of apoptotic DNA fragmentation; positive regulation of apoptotic process; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of B cell apoptotic process; positive regulation of calcium ion transport into cytosol; positive regulation of developmental pigmentation; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of epithelial cell apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of IRE1-mediated unfolded protein response; positive regulation of motor neuron apoptotic process; positive regulation of neuron apoptotic process; positive regulation of protein-containing complex assembly; positive regulation of release of cytochrome c from mitochondria; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of reproductive process; post-embryonic camera-type eye morphogenesis; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; regulation of apoptotic process; regulation of cell cycle; regulation of mammary gland epithelial cell proliferation; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; regulation of mitochondrial membrane potential; regulation of nitrogen utilization; release of cytochrome c from mitochondria; release of matrix enzymes from mitochondria; release of sequestered calcium ion into cytosol; response to axon injury; response to gamma radiation; response to salt stress; response to toxic substance; retina development in camera-type eye; retinal cell programmed cell death; Sertoli cell proliferation; spermatid differentiation; supramolecular fiber organization; T cell homeostatic proliferation; thymocyte apoptotic process; vagina development
Disease: Colorectal Cancer; Leukemia, Acute Lymphoblastic
Reference #:  Q07812 (UniProtKB)
Alt. Names/Synonyms: Apoptosis regulator BAX; BAX; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2 associated X, apoptosis regulator; BCL2-associated X protein; BCL2-associated X protein omega; Bcl2-L-4; BCL2L4
Gene Symbols: BAX
Molecular weight: 21,184 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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BAX

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene