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SynGAP
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Ras |
| Chromosomal Location of Human Ortholog: 6p21.32 |
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Cellular Component:
cytosol; dendritic shaft; glutamatergic synapse; plasma membrane; postsynaptic density
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Molecular Function:
GTPase activator activity; SH3 domain binding
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Biological Process:
dendrite development; maintenance of postsynaptic specialization structure; MAPK cascade; negative regulation of axonogenesis; negative regulation of neuron apoptotic process; negative regulation of Ras protein signal transduction; pattern specification process; positive regulation of GTPase activity; Ras protein signal transduction; receptor clustering; regulation of long-term neuronal synaptic plasticity; regulation of MAPK cascade; regulation of synapse structure or activity; regulation of synaptic plasticity; visual learning
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Disease: Mental Retardation, Autosomal Dominant 5
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Reference #:
Q96PV0
(UniProtKB)
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Alt. Names/Synonyms: DKFZp761G1421; KIAA1938; MRD5; Neuronal RasGAP; Ras GTPase-activating protein SynGAP; Ras/Rap GTPase-activating protein SynGAP; RASA1; RASA5; SYGP1; synaptic Ras GTPase activating protein 1; synaptic Ras GTPase activating protein 1 homolog; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase activating protein, 135kDa; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP; SYNGAP1
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Gene Symbols: SYNGAP1
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Molecular weight:
148,284 Da
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Basal Isoelectric point:
9.12
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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