SynGAP Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of Human Ortholog: 6p21.32
Cellular Component:  cytosol; dendritic shaft; glutamatergic synapse; plasma membrane; postsynaptic density
Molecular Function:  GTPase activator activity; SH3 domain binding
Biological Process:  dendrite development; maintenance of postsynaptic specialization structure; MAPK cascade; negative regulation of axonogenesis; negative regulation of neuron apoptotic process; negative regulation of Ras protein signal transduction; pattern specification process; positive regulation of GTPase activity; Ras protein signal transduction; receptor clustering; regulation of long-term neuronal synaptic plasticity; regulation of MAPK cascade; regulation of synapse structure or activity; regulation of synaptic plasticity; visual learning
Disease: Mental Retardation, Autosomal Dominant 5
Reference #:  Q96PV0 (UniProtKB)
Alt. Names/Synonyms: DKFZp761G1421; KIAA1938; MRD5; Neuronal RasGAP; Ras GTPase-activating protein SynGAP; Ras/Rap GTPase-activating protein SynGAP; RASA1; RASA5; SYGP1; synaptic Ras GTPase activating protein 1; synaptic Ras GTPase activating protein 1 homolog; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase activating protein, 135kDa; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP; SYNGAP1
Gene Symbols: SYNGAP1
Molecular weight: 148,284 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene