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SynGAP
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Ras |
| Chromosomal Location of rat Ortholog: 20p12 |
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Cellular Component:
dendritic shaft; glutamatergic synapse; membrane; plasma membrane; postsynaptic density; postsynaptic density, intracellular component; synapse
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Molecular Function:
GTPase activator activity; protein binding; protein kinase binding; SH3 domain binding
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Biological Process:
axonogenesis; dendrite development; maintenance of postsynaptic specialization structure; modulation of chemical synaptic transmission; negative regulation of axonogenesis; negative regulation of neuron apoptotic process; negative regulation of Ras protein signal transduction; neuron apoptotic process; pattern specification process; Ras protein signal transduction; receptor clustering; regulation of GTPase activity; regulation of long-term neuronal synaptic plasticity; regulation of MAPK cascade; regulation of synapse structure or activity; regulation of synaptic plasticity; visual learning
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Reference #:
Q9QUH6
(UniProtKB)
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Alt. Names/Synonyms: Neuronal RasGAP; p135 SynGAP; Ras GTPase-activating protein SynGAP; Ras/Rap GTPase-activating protein SynGAP; RASA5; SYGP1; synaptic Ras GTPase activating protein 1; synaptic Ras GTPase activating protein 1 homolog (rat); Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; Syngap; Syngap1
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Gene Symbols: Syngap1
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Molecular weight:
144,722 Da
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Basal Isoelectric point:
9.18
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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