SynGAP Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of rat Ortholog: 20p12
Cellular Component:  dendritic shaft; glutamatergic synapse; membrane; plasma membrane; postsynaptic density; postsynaptic density, intracellular component; synapse
Molecular Function:  GTPase activator activity; protein binding; protein kinase binding; SH3 domain binding
Biological Process:  axonogenesis; dendrite development; maintenance of postsynaptic specialization structure; modulation of chemical synaptic transmission; negative regulation of axonogenesis; negative regulation of neuron apoptotic process; negative regulation of Ras protein signal transduction; neuron apoptotic process; pattern specification process; Ras protein signal transduction; receptor clustering; regulation of GTPase activity; regulation of long-term neuronal synaptic plasticity; regulation of MAPK cascade; regulation of synapse structure or activity; regulation of synaptic plasticity; visual learning
Reference #:  Q9QUH6 (UniProtKB)
Alt. Names/Synonyms: Neuronal RasGAP; p135 SynGAP; Ras GTPase-activating protein SynGAP; Ras/Rap GTPase-activating protein SynGAP; RASA5; SYGP1; synaptic Ras GTPase activating protein 1; synaptic Ras GTPase activating protein 1 homolog (rat); Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; Syngap; Syngap1
Gene Symbols: Syngap1
Molecular weight: 144,722 Da
Basal Isoelectric point: 9.18  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene