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ID3
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 1p36.12 |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus
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Molecular Function:
bHLH transcription factor binding; leptomycin B binding; protein binding; protein dimerization activity; protein domain specific binding; transcription regulator activity; transcription regulator inhibitor activity
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Biological Process:
cell differentiation; cellular response to leptomycin B; central nervous system development; circadian regulation of gene expression; epithelial cell differentiation; heart development; metanephros development; muscle organ development; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of myoblast differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription by RNA polymerase II; neuron differentiation; notochord development; odontogenesis; positive regulation of apoptotic process; positive regulation of gene expression; regulation of DNA replication
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Reference #:
Q02535
(UniProtKB)
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Alt. Names/Synonyms: 1R21; BHLHB25; Class B basic helix-loop-helix protein 25; DNA-binding protein inhibitor ID-3; HEIR-1; HEIR1; Helix-loop-helix protein HEIR-1; ID-like protein inhibitor HLH 1R21; ID3; Inhibitor of differentiation 3; Inhibitor of DNA binding 3; inhibitor of DNA binding 3, dominant negative helix-loop-helix protein; inhibitor of DNA binding 3, HLH protein
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Gene Symbols: ID3
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Molecular weight:
12,999 Da
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Basal Isoelectric point:
5.55
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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