NDRG2 Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. Belongs to the NDRG family. Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Tumor suppressor
Chromosomal Location of rat Ortholog: 15p14
Cellular Component:  cytoplasm; glutamatergic synapse; Golgi apparatus; growth cone; nucleus; perinuclear region of cytoplasm
Biological Process:  cell differentiation; negative regulation of cytokine production; negative regulation of ERK1 and ERK2 cascade; negative regulation of smooth muscle cell proliferation; negative regulation of vascular associated smooth muscle cell proliferation; nervous system development; postsynapse organization; regulation of platelet-derived growth factor production; regulation of vascular endothelial growth factor production; signal transduction; substantia nigra development; vascular associated smooth muscle cell proliferation; Wnt signaling pathway
Reference #:  Q8VBU2 (UniProtKB)
Alt. Names/Synonyms: Antidepressant-related protein ADRG123; N-myc downstream regulated gene 2; N-myc downstream-regulated gene 2; NDRG family member 2; NDRG1-related protein; Ndrg2; Protein NDRG2
Gene Symbols: Ndrg2
Molecular weight: 40,779 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NDRG2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene