NDRG2
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. Belongs to the NDRG family. Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Apoptosis; Tumor suppressor |
Chromosomal Location of human Ortholog: 14q11.2 |
Cellular Component:
cytoplasm; cytosol; Golgi apparatus; growth cone; nucleus; perinuclear region of cytoplasm
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Molecular Function:
protein binding
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Biological Process:
cell differentiation; negative regulation of cytokine production; negative regulation of ERK1 and ERK2 cascade; negative regulation of vascular associated smooth muscle cell proliferation; regulation of platelet-derived growth factor production; regulation of vascular endothelial growth factor production; signal transduction; vascular associated smooth muscle cell proliferation; Wnt signaling pathway
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Reference #:
Q9UN36
(UniProtKB)
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Alt. Names/Synonyms: cytoplasmic protein Ndr1; DKFZp781G1938; FLJ25522; KIAA1248; N-myc downstream regulator 2; N-myc downstream-regulated gene 2 protein; NDR1-related protein NDR2; NDRG family member 2; NDRG2; Protein NDRG2; Protein Syld709613; SYLD; syld709613 protein
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Gene Symbols: NDRG2
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Molecular weight:
40,798 Da
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Basal Isoelectric point:
5.08
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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