LDLR
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Belongs to the LDLR family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell surface; Membrane protein, integral; Receptor, misc. |
Chromosomal Location of human Ortholog: 19p13.2 |
Cellular Component:
apical part of cell; basolateral plasma membrane; cell surface; clathrin-coated endocytic vesicle membrane; clathrin-coated pit; early endosome; endolysosome membrane; endosome membrane; external side of plasma membrane; Golgi apparatus; late endosome; low-density lipoprotein particle; lysosome; PCSK9-LDLR complex; plasma membrane; receptor complex; somatodendritic compartment; sorting endosome
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Molecular Function:
amyloid-beta binding; calcium ion binding; clathrin heavy chain binding; identical protein binding; lipoprotein particle binding; low-density lipoprotein particle binding; low-density lipoprotein particle receptor activity; molecular adaptor activity; protease binding; protein binding; very-low-density lipoprotein particle receptor activity; virus receptor activity
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Biological Process:
amyloid-beta clearance; amyloid-beta clearance by cellular catabolic process; artery morphogenesis; cellular response to fatty acid; cellular response to low-density lipoprotein particle stimulus; cholesterol homeostasis; cholesterol import; cholesterol metabolic process; cholesterol transport; endocytosis; high-density lipoprotein particle clearance; intestinal cholesterol absorption; lipid metabolic process; lipoprotein catabolic process; long-term memory; low-density lipoprotein particle clearance; negative regulation of amyloid fibril formation; negative regulation of astrocyte activation; negative regulation of gene expression; negative regulation of low-density lipoprotein particle clearance; negative regulation of microglial cell activation; negative regulation of protein metabolic process; negative regulation of receptor recycling; phagocytosis; phospholipid transport; plasma lipoprotein particle clearance; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of lysosomal protein catabolic process; positive regulation of triglyceride biosynthetic process; receptor-mediated endocytosis; receptor-mediated endocytosis involved in cholesterol transport; regulation of cholesterol metabolic process; regulation of phosphatidylcholine catabolic process; regulation of protein metabolic process; response to caloric restriction; viral entry into host cell
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Disease: Hypercholesterolemia, Familial
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Reference #:
P01130
(UniProtKB)
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Alt. Names/Synonyms: FH; FHC; FHCL1; LDL receptor; LDLCQ2; LDLR; low density lipoprotein receptor; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
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Gene Symbols: LDLR
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Molecular weight:
95,376 Da
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Basal Isoelectric point:
4.86
Predict pI for various phosphorylation states
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