LDLR Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Belongs to the LDLR family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: apical part of cell; basolateral plasma membrane; cell; cell surface; clathrin-coated endocytic vesicle membrane; clathrin-coated pit; early endosome; endolysosome membrane; endosome membrane; external side of plasma membrane; Golgi apparatus; integral component of plasma membrane; late endosome; low-density lipoprotein particle; lysosome; PCSK9-LDLR complex; plasma membrane; receptor complex; somatodendritic compartment; sorting endosome

Molecular Function: amyloid-beta binding; calcium ion binding; clathrin heavy chain binding; identical protein binding; low-density lipoprotein particle binding; low-density lipoprotein particle receptor activity; protease binding; protein binding; very-low-density lipoprotein particle receptor activity; virus receptor activity

Biological Process: amyloid-beta clearance; amyloid-beta clearance by cellular catabolic process; artery morphogenesis; cellular response to fatty acid; cellular response to low-density lipoprotein particle stimulus; cholesterol homeostasis; cholesterol import; cholesterol metabolic process; cholesterol transport; chylomicron remnant clearance; endocytosis; high-density lipoprotein particle clearance; intestinal cholesterol absorption; lipid metabolic process; lipoprotein catabolic process; long-term memory; low-density lipoprotein particle clearance; membrane organization; negative regulation of amyloid fibril formation; negative regulation of astrocyte activation; negative regulation of gene expression; negative regulation of microglial cell activation; negative regulation of protein metabolic process; phagocytosis; phospholipid transport; plasma lipoprotein particle clearance; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of lysosomal protein catabolic process; positive regulation of triglyceride biosynthetic process; receptor-mediated endocytosis; receptor-mediated endocytosis involved in cholesterol transport; regulation of cholesterol metabolic process; regulation of phosphatidylcholine catabolic process; regulation of protein metabolic process; response to caloric restriction; viral entry into host cell

Disease: Hypercholesterolemia, Familial

Reference #: P01130 (UniProtKB)

Alt. Names/Synonyms: FH; FHC; FHCL1; LDL receptor; LDLCQ2; LDLR; low density lipoprotein receptor; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3

Gene Symbols: LDLR

Molecular weight: 95,376 Da

Basal Isoelectric point: 4.86 Predict pI for various phosphorylation states

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LDLR

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