SREBP-2 Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. Belongs to the SREBP family. Ubiquitously expressed in adult and fetal tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor
Chromosomal Location of human Ortholog: 22q13.2
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane; Golgi membrane; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus; SREBP-SCAP-Insig complex
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein binding; protein C-terminus binding; protein dimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  cellular response to laminar fluid shear stress; cellular response to low-density lipoprotein particle stimulus; cellular response to starvation; cholesterol homeostasis; cholesterol metabolic process; lipid metabolic process; negative regulation of cholesterol efflux; negative regulation of transcription by RNA polymerase II; positive regulation of cholesterol storage; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of cholesterol biosynthetic process; regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
Reference #:  Q12772 (UniProtKB)
Alt. Names/Synonyms: BHLHD2; Class D basic helix-loop-helix protein 2; Processed sterol regulatory element-binding protein 2; SRBP2; SREBF2; SREBP-2; SREBP2; sterol regulatory element binding transcription factor 2; Sterol regulatory element-binding protein 2; Sterol regulatory element-binding transcription factor 2; Transcription factor SREBF2
Gene Symbols: SREBF2
Molecular weight: 123,688 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB