SLC18A3 Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. Peripheral and central cholinergic nervous systems. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of mouse Ortholog: 14 B|14 19.4 cM
Cellular Component:  AP-1 adaptor complex; AP-2 adaptor complex; axon; axon terminus; cholinergic synapse; cytoplasm; cytoplasmic vesicle; integral component of synaptic vesicle membrane; neuromuscular junction; neuron projection; synaptic vesicle; terminal bouton
Molecular Function:  acetylcholine transmembrane transporter activity; monoamine transmembrane transporter activity; protein binding
Biological Process:  acetylcholine transport; neurotransmitter loading into synaptic vesicle
Reference #:  O35304 (UniProtKB)
Alt. Names/Synonyms: Slc18a3; solute carrier family 18 (vesicular monoamine), member 3; Solute carrier family 18 member 3; VAC; VAChT; VAT; Vesicular acetylcholine transporter
Gene Symbols: Slc18a3
Molecular weight: 56,615 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene