Kv-beta2 Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes KCNA4 channel closure. Modulates the functional properties of KCNA5. Enhances KCNB2 channel activity. Binds NADPH and has NADPH-dependent aldoketoreductase activity. Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro). Belongs to the shaker potassium channel beta subunit family. Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in hippocampus (PubMed:7649300). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium
Chromosomal Location of human Ortholog: 1p36.31
Cellular Component:  axon terminus; cell junction; cytosol; extrinsic component of cytoplasmic side of plasma membrane; juxtaparanode region of axon; membrane; pinceau fiber; plasma membrane; postsynaptic density; specific granule membrane; tertiary granule membrane; voltage-gated potassium channel complex
Molecular Function:  aldo-keto reductase (NADP) activity; potassium channel regulator activity; voltage-gated potassium channel activity
Biological Process:  hematopoietic progenitor cell differentiation; NADPH oxidation; neuromuscular process; neutrophil degranulation; oxidation-reduction process; potassium ion transmembrane transport; regulation of potassium ion transmembrane transport; regulation of protein localization to cell surface
Reference #:  Q13303 (UniProtKB)
Alt. Names/Synonyms: AKR6A5; hKvbeta2; HKvbeta2.1; HKvbeta2.2; K(+) channel subunit beta-2; K+ channel beta-2 subunit; KCAB2; KCNA2B; KCNAB2; KCNK2; Kv-beta-2; Kv-beta2; MGC117289; potassium channel shaker chain beta 2; potassium channel, voltage gated subfamily A regulatory beta subunit 2; potassium voltage-gated channel subfamily A regulatory beta subunit 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; Voltage-gated potassium channel subunit beta-2
Gene Symbols: KCNAB2
Molecular weight: 41,000 Da
Basal Isoelectric point: 9.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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