a Galpha-protein coupled receptor for endogenous cannabinoids. Ligands inclide anandamide, 2-AG, and phytocannabinoids such as THC. Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase, thus reducing cyclic AMP concentrations. Inhibits L-type Ca(2+) channel current. Has been reported to influence food intake, memory, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, and chronic pain. High-fat diet increases the hepatic levels of CNR1 ligand anandamide, but not that of 2-arachidonoylglycerol. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Isoform 2 and isoform 3 have altered ligand binding. Isoform 1 binds both 2-AG and anandamide, while Isoforms 2 and 3 only binds 2-AG with high affinity. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component: axon; GABA-ergic synapse; glutamatergic synapse; growth cone; integral component of mitochondrial membrane; integral component of presynaptic membrane; membrane raft; mitochondrial outer membrane; mitochondrion; plasma membrane; presynapse; presynaptic membrane
Molecular Function: cannabinoid receptor activity; drug binding; protein binding; voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
Biological Process: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; aging; axonal fasciculation; cannabinoid signaling pathway; G protein-coupled receptor signaling pathway; glucose homeostasis; induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration; learning or memory; maternal process involved in female pregnancy; memory; negative regulation of action potential; negative regulation of blood pressure; negative regulation of dopamine secretion; negative regulation of fatty acid beta-oxidation; negative regulation of ion transport; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; positive regulation of acute inflammatory response to antigenic stimulus; positive regulation of apoptotic process; positive regulation of blood pressure; positive regulation of fever generation; positive regulation of neuron projection development; regulation of feeding behavior; regulation of insulin secretion; regulation of lipid metabolic process; regulation of penile erection; regulation of synaptic transmission, GABAergic; regulation of synaptic transmission, glutamatergic; response to cocaine; response to ethanol; response to lipopolysaccharide; response to morphine; response to nicotine; response to nutrient; retrograde trans-synaptic signaling by endocannabinoid; sensory perception of pain; spermatogenesis; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission