TXA2-R Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 19p13.3
Cellular Component:  acrosomal vesicle; integral component of plasma membrane; nuclear speck; plasma membrane
Molecular Function:  guanyl-nucleotide exchange factor activity; protein binding; thromboxane A2 receptor activity
Biological Process:  cellular response to lipopolysaccharide; G protein-coupled receptor signaling pathway; negative regulation of cell migration involved in sprouting angiogenesis; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of smooth muscle contraction; response to ethanol; response to nutrient; response to testosterone; thromboxane A2 signaling pathway
Reference #:  P21731 (UniProtKB)
Alt. Names/Synonyms: BDPLT13; prostanoid TP receptor; TA2R; TBXA2R; Thromboxane A2 receptor; TXA2-R
Gene Symbols: TBXA2R
Molecular weight: 37,431 Da
Basal Isoelectric point: 10  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein