Rb-like 1 Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. Belongs to the retinoblastoma protein (RB) family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of Human Ortholog: 2 H1|2 78.05 cM
Cellular Component:  chromatin; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  promoter-specific chromatin binding; protein binding; RNA polymerase II activating transcription factor binding; RNA polymerase II regulatory region DNA binding; transcription factor binding
Biological Process:  cell cycle; cell differentiation; chromatin organization; negative regulation of cellular senescence; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of cell division; regulation of lipid kinase activity; regulation of mitotic cell cycle; regulation of transcription by RNA polymerase II
Reference #:  Q64701 (UniProtKB)
Alt. Names/Synonyms: 107 kDa retinoblastoma-associated protein; AW547426; OTTMUSP00000017311; p107; pRb1; Rbl1; retinoblastoma-like 1 (p107); Retinoblastoma-like protein 1
Gene Symbols: Rbl1
Molecular weight: 119,456 Da
Basal Isoelectric point: 7.31  Predict pI for various phosphorylation states
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Rb-like 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene