|
DNAM-1
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding. Expressed by peripheral blood T-lymphocytes. Note: This description may include information from UniProtKB.
|
| Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 18q22.2 |
|
Cellular Component:
cell surface; external side of plasma membrane; membrane raft; plasma membrane
|
|
Molecular Function:
cell adhesion molecule binding; identical protein binding; integrin binding; protein binding; protein kinase binding
|
|
Biological Process:
cell adhesion; cell recognition; cytokine production; positive regulation of Fc receptor mediated stimulatory signaling pathway; positive regulation of immunoglobulin mediated immune response; positive regulation of mast cell activation; positive regulation of natural killer cell cytokine production; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of T cell receptor signaling pathway; positive regulation of type II interferon production; signal transduction
|
|
Reference #:
Q15762
(UniProtKB)
|
|
Alt. Names/Synonyms: adhesion glycoprotein; CD226; CD226 antigen; CD226 molecule; DNAM-1; DNAM1; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; PTA1; T lineage-specific activation antigen 1 antigen; TLiSA1
|
|
Gene Symbols: CD226
|
|
Molecular weight:
38,614 Da
|
|
Basal Isoelectric point:
8.11
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
