DNAM-1 Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding. Expressed by peripheral blood T-lymphocytes. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q22.2
Cellular Component:  cell surface; integral component of plasma membrane; membrane raft; plasma membrane
Molecular Function:  cell adhesion molecule binding; integrin binding; protein binding; protein kinase binding
Biological Process:  cell adhesion; cell recognition; positive regulation of Fc receptor mediated stimulatory signaling pathway; positive regulation of immunoglobulin mediated immune response; positive regulation of mast cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of T cell receptor signaling pathway; regulation of immune response; signal transduction
Reference #:  Q15762 (UniProtKB)
Alt. Names/Synonyms: adhesion glycoprotein; CD226; CD226 antigen; CD226 molecule; DNAM-1; DNAM1; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; PTA1; T lineage-specific activation antigen 1 antigen; TLiSA1
Gene Symbols: CD226
Molecular weight: 38,614 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DNAM-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB