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DNAM-1
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding. Expressed by peripheral blood T-lymphocytes. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 18q22.2 |
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Cellular Component:
cell surface; integral component of plasma membrane; membrane raft; plasma membrane
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Molecular Function:
cell adhesion molecule binding; integrin binding; protein binding; protein kinase binding
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Biological Process:
cell adhesion; cell recognition; positive regulation of Fc receptor mediated stimulatory signaling pathway; positive regulation of immunoglobulin mediated immune response; positive regulation of mast cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of T cell receptor signaling pathway; regulation of immune response; signal transduction
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Reference #:
Q15762
(UniProtKB)
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Alt. Names/Synonyms: adhesion glycoprotein; CD226; CD226 antigen; CD226 molecule; DNAM-1; DNAM1; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; PTA1; T lineage-specific activation antigen 1 antigen; TLiSA1
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Gene Symbols: CD226
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Molecular weight:
38,614 Da
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Basal Isoelectric point:
8.11
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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