RAI1 Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. Expressed in all tissues examined with higher expression in the heart and brain. No expression was seen in the corpus callosum of the brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of human Ortholog: 17p11.2
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  metal ion binding; protein binding
Biological Process:  circadian regulation of gene expression; negative regulation of multicellular organism growth; positive regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; skeletal system development
Disease: Smith-magenis Syndrome
Reference #:  Q7Z5J4 (UniProtKB)
Alt. Names/Synonyms: DKFZp434A139; KIAA1820; MGC12824; RAI1; retinoic acid induced 1; Retinoic acid-induced protein 1; SMCR; Smith-Magenis syndrome chromosome region; SMS
Gene Symbols: RAI1
Molecular weight: 203,352 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein