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PTGIR
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of Human Ortholog: 19q13.32 |
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Cellular Component:
cytosol; integral component of plasma membrane; plasma membrane
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Molecular Function:
G protein-coupled receptor activity; guanyl-nucleotide exchange factor activity
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; cell-cell signaling; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of smooth muscle cell proliferation; response to lipopolysaccharide
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Reference #:
P43119
(UniProtKB)
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Alt. Names/Synonyms: IP; MGC102830; PGI receptor; PGI2 receptor; PI2R; PRIPR; Prostacyclin receptor; prostaglandin I2 (prostacyclin) receptor (IP); Prostaglandin I2 receptor; Prostanoid IP receptor; PTGIR
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Gene Symbols: PTGIR
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Molecular weight:
40,956 Da
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Basal Isoelectric point:
8.9
Predict pI for various phosphorylation states
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