PTGIR Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 19q13.32
Cellular Component:  cytosol; integral component of plasma membrane; plasma membrane
Molecular Function:  G protein-coupled receptor activity; guanyl-nucleotide exchange factor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; cell-cell signaling; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of smooth muscle cell proliferation; response to lipopolysaccharide
Reference #:  P43119 (UniProtKB)
Alt. Names/Synonyms: IP; MGC102830; PGI receptor; PGI2 receptor; PI2R; PRIPR; Prostacyclin receptor; prostaglandin I2 (prostacyclin) receptor (IP); Prostaglandin I2 receptor; Prostanoid IP receptor; PTGIR
Gene Symbols: PTGIR
Molecular weight: 40,956 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene