Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 126.96.36.199; Motility/polarity/chemotaxis; Protease
Molecular Function: aspartic-type endopeptidase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; death receptor binding; peptidase activity; phospholipase A2 activator activity; protease binding; protein binding; protein-containing complex binding
Biological Process: apoptotic DNA fragmentation; apoptotic process; apoptotic signaling pathway; axonal fasciculation; B cell homeostasis; cell fate commitment; cellular response to DNA damage stimulus; cellular response to staurosporine; cytokine-mediated signaling pathway; erythrocyte differentiation; execution phase of apoptosis; extrinsic apoptotic signaling pathway in absence of ligand; glial cell apoptotic process; heart development; hippo signaling; hippocampus development; intrinsic apoptotic signaling pathway in response to osmotic stress; learning or memory; leukocyte apoptotic process; luteolysis; negative regulation of activated T cell proliferation; negative regulation of apoptotic process; negative regulation of B cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; neuron apoptotic process; neurotrophin TRK receptor signaling pathway; platelet formation; positive regulation of amyloid-beta formation; positive regulation of catalytic activity; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of macroautophagy; regulation of protein stability; response to amino acid; response to cobalt ion; response to estradiol; response to glucocorticoid; response to glucose; response to hydrogen peroxide; response to hypoxia; response to lipopolysaccharide; response to nicotine; response to tumor necrosis factor; response to UV; response to X-ray; sensory perception of sound; striated muscle cell differentiation; T cell homeostasis; wound healing