AK5 Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. Belongs to the adenylate kinase family. Brain specific. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Kinase, other; Nucleotide Metabolism - purine
Chromosomal Location of human Ortholog: 1p31.1
Cellular Component:  centriolar satellite; cytoplasm; cytosol
Molecular Function:  adenylate kinase activity; ATP binding; nucleoside diphosphate kinase activity
Biological Process:  ADP biosynthetic process; ATP metabolic process; dADP biosynthetic process; nucleoside diphosphate phosphorylation; nucleoside monophosphate phosphorylation; nucleoside triphosphate biosynthetic process; pyrimidine ribonucleotide biosynthetic process
Reference #:  Q9Y6K8 (UniProtKB)
Alt. Names/Synonyms: adenylate kinase 5; adenylate kinase 6; Adenylate kinase isoenzyme 5; AK 5; AK5; AK6; ATP-AMP transphosphorylase 5; KAD5; MGC33326
Gene Symbols: AK5
Molecular weight: 63,333 Da
Basal Isoelectric point: 4.96  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein