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AK5
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. Belongs to the adenylate kinase family. Brain specific. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.4.3; EC 2.7.4.6; Kinase, other; Nucleotide Metabolism - purine |
| Chromosomal Location of human Ortholog: 1p31.1 |
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Cellular Component:
centriolar satellite; cytoplasm; cytosol
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Molecular Function:
adenylate kinase activity; ATP binding; nucleoside diphosphate kinase activity
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Biological Process:
ADP biosynthetic process; ATP metabolic process; dADP biosynthetic process; nucleoside diphosphate phosphorylation; nucleoside monophosphate phosphorylation; nucleoside triphosphate biosynthetic process; pyrimidine ribonucleotide biosynthetic process
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Reference #:
Q9Y6K8
(UniProtKB)
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Alt. Names/Synonyms: adenylate kinase 5; adenylate kinase 6; Adenylate kinase isoenzyme 5; AK 5; AK5; AK6; ATP-AMP transphosphorylase 5; KAD5; MGC33326
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Gene Symbols: AK5
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Molecular weight:
63,333 Da
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Basal Isoelectric point:
4.96
Predict pI for various phosphorylation states
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