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TSSK2
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Testis-specific. Present in mature spermatozoa (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); TSSK family |
| Chromosomal Location of human Ortholog: 22q11.21 |
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Cellular Component:
acrosomal vesicle; centriole; cytoplasm; nucleotide-activated protein kinase complex
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Molecular Function:
ATP binding; magnesium ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding
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Biological Process:
cellular response to glucose starvation; intracellular signal transduction; negative regulation of TOR signaling; peptidyl-serine phosphorylation; protein autophosphorylation; protein phosphorylation; spermatid development
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Reference #:
Q96PF2
(UniProtKB)
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Alt. Names/Synonyms: DGS-G; DGSG; DiGeorge syndrome protein G; FLJ38613; serine/threonine kinase 22B (spermiogenesis associated); Serine/threonine-protein kinase 22B; spermiogenesis associated 2; SPOGA2; STK22B; testicular secretory protein Li 61; testis specific serine kinase 2; testis specific serine threonine kinase 2; Testis-specific kinase 2; testis-specific serine kinase 2; Testis-specific serine/threonine-protein kinase 2; TSK-2; TSK2; TSSK-2; TSSK2
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Gene Symbols: TSSK2
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Molecular weight:
40,939 Da
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Basal Isoelectric point:
9.02
Predict pI for various phosphorylation states
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