TSSK2 Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Testis-specific. Present in mature spermatozoa (at protein level). Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); TSSK family
Chromosomal Location of Human Ortholog: 16 A3|16 11.09 cM
Cellular Component:  acrosomal vesicle; centriole; cytoplasm; cytoplasmic vesicle; cytoskeleton; nucleus
Molecular Function:  ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transferase activity
Biological Process:  cell differentiation; intracellular signal transduction; multicellular organism development; peptidyl-serine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; spermatid development; spermatogenesis
Reference #:  O54863 (UniProtKB)
Alt. Names/Synonyms: DGS-; DGS-G; serine/threonine kinase 22B (spermiogenesis associated); Serine/threonine-protein kinase 22B; SPOGA2; Stk22; Stk22b; testis specific serine/ threonine kinase 2; Testis-specific kinase 2; testis-specific serine kinase 2; Testis-specific serine/threonine-protein kinase 2; Tsk; TSK-2; Tsk2; TSSK-2; Tssk2
Gene Symbols: Tssk2
Molecular weight: 41,022 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene