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AHR
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription. Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 7p21.1 |
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Cellular Component:
aryl hydrocarbon receptor complex; chromatin; cytoplasm; cytosol; cytosolic aryl hydrocarbon receptor complex; nuclear aryl hydrocarbon receptor complex; nucleoplasm; nucleus; protein-containing complex; transcription regulator complex
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Molecular Function:
cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; Hsp90 protein binding; nuclear receptor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding; TBP-class protein binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; transcription coactivator binding
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Biological Process:
apoptotic process; blood vessel development; cAMP-mediated signaling; cell cycle; cellular response to 2,3,7,8-tetrachlorodibenzodioxine; cellular response to cAMP; cellular response to forskolin; cellular response to molecule of bacterial origin; circadian regulation of gene expression; intracellular receptor signaling pathway; negative regulation of DNA-templated transcription; negative regulation of inflammatory response; negative regulation of T cell mediated immune response to tumor cell; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of adaptive immune response; regulation of B cell proliferation; regulation of DNA-templated transcription; regulation of gene expression; regulation of transcription by RNA polymerase II; response to toxic substance; response to xenobiotic stimulus; xenobiotic metabolic process
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Disease: Retinitis Pigmentosa 85
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Reference #:
P35869
(UniProtKB)
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Alt. Names/Synonyms: Ah receptor; AH-receptor; AHR; aromatic hydrocarbon receptor; Aryl hydrocarbon receptor; BHLHE76; Class E basic helix-loop-helix protein 76; RP85
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Gene Symbols: AHR
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Molecular weight:
96,147 Da
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Basal Isoelectric point:
5.94
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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