AHR Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription. Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 12 A3|12 15.78 cM
Cellular Component:  aryl hydrocarbon receptor complex; cytoplasm; cytosol; cytosolic aryl hydrocarbon receptor complex; nuclear aryl hydrocarbon receptor complex; nucleus; protein-containing complex; transcription regulator complex
Molecular Function:  aryl hydrocarbon receptor binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; Hsp90 protein binding; identical protein binding; nuclear receptor activity; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; protein-folding chaperone binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; TBP-class protein binding; TFIID-class transcription factor complex binding; toxic substance binding; transcription cis-regulatory region binding; transcription coactivator binding
Biological Process:  B cell differentiation; B cell homeostasis; B-1 B cell homeostasis; blood circulation; blood vessel development; blood vessel morphogenesis; blood vessel remodeling; branching involved in blood vessel morphogenesis; camera-type eye development; cAMP-mediated signaling; cardiac left ventricle morphogenesis; cell cycle; cell morphogenesis; cellular response to 2,3,7,8-tetrachlorodibenzodioxine; cellular response to 3-methylcholanthrene; cellular response to cAMP; cellular response to forskolin; cellular response to molecule of bacterial origin; circadian regulation of gene expression; circumferential growth involved in left ventricle morphogenesis; gland development; glomerulus morphogenesis; immune system process; kidney morphogenesis; liver development; lymphocyte homeostasis; negative regulation of alkaline phosphatase activity; negative regulation of calcium ion transmembrane transport; negative regulation of DNA biosynthetic process; negative regulation of DNA-templated transcription; negative regulation of inflammatory response; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of systemic arterial blood pressure; negative regulation of T cell mediated immune response to tumor cell; negative regulation of transcription by RNA polymerase II; negative regulation of vasoconstriction; ovarian follicle development; positive regulation of cell size; positive regulation of DNA-templated transcription; positive regulation of growth rate; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; post-embryonic hemopoiesis; prostate gland development; regulation of adaptive immune response; regulation of B cell proliferation; regulation of DNA-templated transcription; regulation of gene expression; regulation of heart growth; regulation of transcription by RNA polymerase II; reproductive structure development; response to organic cyclic compound; response to toxic substance; response to xenobiotic stimulus; rhythmic process; spleen development; T cell homeostasis; transcription by RNA polymerase II; vasculature development; xenobiotic metabolic process
Reference #:  P30561 (UniProtKB)
Alt. Names/Synonyms: Ah; Ah receptor; Ahh; AhR; Ahre; Aryl hydrocarbon receptor; aryl-hydrocarbon receptor; bHLHe7; bHLHe76; dioxin receptor; In
Gene Symbols: Ahr
Molecular weight: 95,017 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene