GH Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Belongs to the somatotropin/prolactin family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 11 E1|11 68.89 cM
Cellular Component:  collagen-containing extracellular matrix; cytosol; endoplasmic reticulum; extracellular region; extracellular space; growth hormone receptor complex; mitochondrion; nucleus; plasma membrane; secretory granule; trans-Golgi network; vesicle
Molecular Function:  growth factor activity; growth hormone receptor binding; hormone activity; metal ion binding; prolactin receptor binding
Biological Process:  animal organ development; cellular response to insulin stimulus; growth hormone receptor signaling pathway; lung alveolus development; negative regulation of neuron death; neuroblast proliferation; positive regulation of glucose transmembrane transport; positive regulation of growth; positive regulation of multicellular organism growth; positive regulation of neurogenesis; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of steroid hormone biosynthetic process; positive regulation of tyrosine phosphorylation of STAT protein; regulation of intracellular steroid hormone receptor signaling pathway; response to food; response to light stimulus; response to nutrient levels
Reference #:  P06880 (UniProtKB)
Alt. Names/Synonyms: Gh; Gh1; Ghb1; Growth hormone; growth hormone b1; OTTMUSP00000003470; SOMA; Somatotropin
Gene Symbols: Gh1
Molecular weight: 24,716 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene