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GH
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Belongs to the somatotropin/prolactin family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Hormone; Secreted; Secreted, signal peptide |
| Chromosomal Location of Human Ortholog: 11 E1|11 68.89 cM |
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Cellular Component:
collagen-containing extracellular matrix; cytosol; extracellular region; extracellular space; mitochondrion; nucleus; plasma membrane; secretory granule; trans-Golgi network
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Molecular Function:
growth factor activity; growth hormone receptor binding; hormone activity; metal ion binding
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Biological Process:
animal organ development; cellular response to insulin stimulus; growth hormone receptor signaling pathway; lung alveolus development; negative regulation of neuron death; neuroblast proliferation; positive regulation of glucose transmembrane transport; positive regulation of growth; positive regulation of JAK-STAT cascade; positive regulation of multicellular organism growth; positive regulation of neurogenesis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of steroid hormone biosynthetic process; positive regulation of tyrosine phosphorylation of STAT protein; regulation of intracellular steroid hormone receptor signaling pathway; response to food; response to light stimulus; response to nutrient levels
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Reference #:
P06880
(UniProtKB)
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Alt. Names/Synonyms: Gh; Gh1; Ghb1; Growth hormone; growth hormone b1; OTTMUSP00000003470; SOMA; Somatotropin
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Gene Symbols: Gh1
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Molecular weight:
24,716 Da
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Basal Isoelectric point:
5.97
Predict pI for various phosphorylation states
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