DYN3 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.5.5; Hydrolase; Microtubule-binding; Mitochondrial; Motility/polarity/chemotaxis; Motor; Vesicle
Chromosomal Location of human Ortholog: 1q24.3
Cellular Component:  apical tubulobulbar complex; axon; basal tubulobulbar complex; cytoplasm; dendritic spine; dendritic spine head; glutamatergic synapse; microtubule; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic endocytic zone membrane; presynapse; synaptic cleft
Molecular Function:  GTP binding; GTPase activity; microtubule binding; nitric-oxide synthase binding; protein binding; protein serine/threonine kinase binding; structural constituent of postsynapse; type 1 metabotropic glutamate receptor binding; type 5 metabotropic glutamate receptor binding
Biological Process:  endocytosis; filopodium assembly; negative regulation of dendritic spine morphogenesis; positive regulation of filopodium assembly; positive regulation of synaptic vesicle recycling; postsynapse organization; postsynaptic neurotransmitter receptor internalization; receptor internalization; synapse assembly; synaptic vesicle endocytosis
Reference #:  Q9UQ16 (UniProtKB)
Alt. Names/Synonyms: DNM3; DYN3; Dyna III; dynamin 3; dynamin family member; Dynamin, testicular; Dynamin-3; KIAA0820; MGC70433; T-dynamin
Gene Symbols: DNM3
Molecular weight: 97,746 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DYN3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein