DYN3
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.6.5.5; Hydrolase; Microtubule-binding; Mitochondrial; Motility/polarity/chemotaxis; Motor; Vesicle |
Chromosomal Location of human Ortholog: 1q24.3 |
Cellular Component:
apical tubulobulbar complex; axon; basal tubulobulbar complex; cytoplasm; dendritic spine; dendritic spine head; glutamatergic synapse; microtubule; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic endocytic zone membrane; presynapse; synaptic cleft
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Molecular Function:
GTP binding; GTPase activity; microtubule binding; nitric-oxide synthase binding; protein binding; protein serine/threonine kinase binding; structural constituent of postsynapse; type 1 metabotropic glutamate receptor binding; type 5 metabotropic glutamate receptor binding
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Biological Process:
endocytosis; filopodium assembly; negative regulation of dendritic spine morphogenesis; positive regulation of filopodium assembly; positive regulation of synaptic vesicle recycling; postsynapse organization; postsynaptic neurotransmitter receptor internalization; receptor internalization; synapse assembly; synaptic vesicle endocytosis
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Reference #:
Q9UQ16
(UniProtKB)
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Alt. Names/Synonyms: DNM3; DYN3; Dyna III; dynamin 3; dynamin family member; Dynamin, testicular; Dynamin-3; KIAA0820; MGC70433; T-dynamin
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Gene Symbols: DNM3
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Molecular weight:
97,746 Da
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Basal Isoelectric point:
8.51
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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