DYN3 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Microtubule-binding; Mitochondrial; Motility/polarity/chemotaxis; Motor; Vesicle
Chromosomal Location of rat Ortholog: 13q22
Cellular Component:  apical tubulobulbar complex; axon; basal tubulobulbar complex; cytoplasm; cytoplasmic vesicle; cytosol; dendritic spine; dendritic spine head; glutamatergic synapse; Golgi apparatus; membrane; microtubule; perinuclear region of cytoplasm; photoreceptor inner segment; plasma membrane; postsynaptic density; postsynaptic endocytic zone membrane; postsynaptic membrane; presynapse; synapse; synaptic cleft
Molecular Function:  GTP binding; GTPase activity; identical protein binding; microtubule binding; nitric-oxide synthase binding; protein binding; structural constituent of postsynapse; type 1 metabotropic glutamate receptor binding; type 5 metabotropic glutamate receptor binding
Biological Process:  endocytosis; filopodium assembly; negative regulation of dendritic spine morphogenesis; positive regulation of filopodium assembly; positive regulation of synaptic vesicle recycling; postsynapse organization; postsynaptic neurotransmitter receptor internalization; receptor internalization; regulation of dendritic spine morphogenesis; regulation of synapse structure or activity; sperm ejaculation; synapse assembly; synaptic vesicle budding from presynaptic endocytic zone membrane; synaptic vesicle endocytosis
Reference #:  Q08877 (UniProtKB)
Alt. Names/Synonyms: Dnm3; Dyn3; dynamin 3; Dynamin, testicular; dynamin-2; Dynamin-3; T-dynamin; testicular dynamin
Gene Symbols: Dnm3
Molecular weight: 97,914 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene