mGluR7 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4q41
Cellular Component:  asymmetric synapse; axon; axon terminus; cell cortex; cell surface; dendrite; dendritic shaft; GABA-ergic synapse; glutamatergic synapse; Golgi apparatus; integral component of membrane; integral component of plasma membrane; integral component of presynaptic active zone membrane; integral component of presynaptic membrane; membrane; neuronal cell body; plasma membrane; postsynaptic membrane; presynaptic active zone; presynaptic membrane; protein-containing complex; receptor complex; rough endoplasmic reticulum; synapse; terminal bouton
Molecular Function:  adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; adenylate cyclase inhibitor activity; calcium channel regulator activity; calcium ion binding; calcium-dependent protein binding; calmodulin binding; G protein-coupled receptor activity; glutamate binding; glutamate receptor activity; group III metabotropic glutamate receptor activity; PDZ domain binding; protein binding; protein homodimerization activity; serine binding; voltage-gated calcium channel activity
Biological Process:  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adult behavior; associative learning; behavioral fear response; chemical synaptic transmission; conditioned taste aversion; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; learning or memory; memory; multicellular organismal response to stress; negative regulation of glutamate secretion; negative regulation of neuron apoptotic process; nervous system process; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle exocytosis; sensory perception of sound; short-term memory; transmission of nerve impulse
Reference #:  P35400 (UniProtKB)
Alt. Names/Synonyms: glutamate receptor, metabotropic 7; Gprc1g; Grm7; Metabotropic glutamate receptor 7; metabotropic glutamate receptor mGluR7; metabotropic glutamate receptor subtype 7b; Mglur7
Gene Symbols: Grm7
Molecular weight: 102,232 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene