Galanin Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion. Belongs to the galanin family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component:  extracellular region; extracellular space; Golgi apparatus; neuronal cell body
Molecular Function:  galanin receptor activity; neuropeptide hormone activity; protein binding; type 1 galanin receptor binding; type 2 galanin receptor binding; type 3 galanin receptor binding
Biological Process:  cAMP-mediated signaling; feeding behavior; G protein-coupled receptor signaling pathway; inflammatory response; insulin secretion; negative regulation of lymphocyte proliferation; negative regulation of root hair elongation; positive regulation of apoptotic process; positive regulation of cortisol secretion; positive regulation of large conductance calcium-activated potassium channel activity; positive regulation of timing of catagen; positive regulation of transcription by RNA polymerase II; protein kinase A signaling; regulation of glucocorticoid metabolic process; regulation of signaling receptor activity; response to drug; response to estrogen; response to immobilization stress; response to insulin
Disease: Epilepsy, Familial Temporal Lobe, 8
Reference #:  P22466 (UniProtKB)
Alt. Names/Synonyms: GAL; GAL1; GALA; Galanin; Galanin message-associated peptide; Galanin peptides; galanin prepropeptide; galanin-message-associated peptide; galanin-related peptide; GALN; GLNN; GMAP; MGC40167
Gene Symbols: GAL
Molecular weight: 13,302 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene