Galanin Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion. Belongs to the galanin family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 11q13.2
Cellular Component:  extracellular region; extracellular space; neuronal cell body; secretory granule
Molecular Function:  galanin receptor activity; galanin receptor binding; neuropeptide hormone activity; protein binding; type 1 galanin receptor binding; type 2 galanin receptor binding; type 3 galanin receptor binding
Biological Process:  cAMP-mediated signaling; feeding behavior; insulin secretion; negative regulation of lymphocyte proliferation; neuropeptide signaling pathway; positive regulation of apoptotic process; positive regulation of cortisol secretion; positive regulation of large conductance calcium-activated potassium channel activity; positive regulation of timing of catagen; positive regulation of transcription by RNA polymerase II; protein kinase A signaling; regulation of glucocorticoid metabolic process; response to estrogen; response to immobilization stress; response to insulin; response to xenobiotic stimulus
Disease: Epilepsy, Familial Temporal Lobe, 8
Reference #:  P22466 (UniProtKB)
Alt. Names/Synonyms: ETL8; GAL; GAL-GMAP; GAL1; GALA; Galanin; galanin and GMAP prepropeptide; Galanin message-associated peptide; Galanin peptides; galanin prepropeptide; galanin-message-associated peptide; galanin-related peptide; galanin/GMAP prepropeptide; GALN; GLNN; GMAP; MGC40167
Gene Symbols: GAL
Molecular weight: 13,302 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein