GH Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Belongs to the somatotropin/prolactin family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component:  endosome lumen; extracellular region; extracellular space; growth hormone receptor complex
Molecular Function:  growth factor activity; growth hormone receptor binding; metal ion binding; prolactin receptor binding; protein binding
Biological Process:  bone maturation; growth hormone receptor signaling pathway; JAK-STAT cascade involved in growth hormone signaling pathway; positive regulation of activation of Janus kinase activity; positive regulation of glucose transmembrane transport; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of JAK-STAT cascade; positive regulation of MAP kinase activity; positive regulation of multicellular organism growth; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; response to estradiol
Disease: Isolated Growth Hormone Deficiency, Type Ia; Isolated Growth Hormone Deficiency, Type Ib; Isolated Growth Hormone Deficiency, Type Ii; Kowarski Syndrome
Reference #:  P01241 (UniProtKB)
Alt. Names/Synonyms: GH; GH-N; GH1; GHB5; GHN; Growth hormone; Growth hormone 1; growth hormone B5; hGH-N; IGHD1A; IGHD1B; IGHD2; Pituitary growth hormone; SOMA; Somatotropin
Gene Symbols: GH1
Molecular weight: 24,847 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
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GH

Protein Structure Not Found.


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