ICAM1 ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. Belongs to the immunoglobulin superfamily. ICAM family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of rat Ortholog: 8q13
Cellular Component:  cell surface; external side of plasma membrane; extracellular exosome; extracellular space; immunological synapse; membrane raft; plasma membrane
Molecular Function:  integrin binding; protein-containing complex binding
Biological Process:  acute inflammatory response to antigenic stimulus; cell adhesion; cell adhesion mediated by integrin; cell-cell adhesion; cellular response to alkaloid; cellular response to amyloid-beta; cellular response to dexamethasone stimulus; cellular response to glucose stimulus; cellular response to hypoxia; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to leukemia inhibitory factor; cellular response to lipopolysaccharide; cellular response to nutrient levels; cellular response to organic substance; cellular response to tumor necrosis factor; cellular response to type II interferon; cellular senescence; establishment of endothelial barrier; establishment of endothelial intestinal barrier; establishment of Sertoli cell barrier; leukocyte cell-cell adhesion; leukocyte migration; membrane to membrane docking; negative regulation of calcium ion transport; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; ovarian follicle development; positive regulation of actin filament polymerization; positive regulation of cellular extravasation; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell apoptotic process; positive regulation of vasoconstriction; regulation of activated T cell proliferation; regulation of cell shape; regulation of ruffle assembly; response to amino acid; response to amphetamine; response to copper ion; response to ethanol; response to gonadotropin; response to hypoxia; response to insulin; response to ionizing radiation; response to lipopolysaccharide; response to organic cyclic compound; response to sulfur dioxide; response to xenobiotic stimulus; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; T cell antigen processing and presentation; T cell extravasation
Reference #:  Q00238 (UniProtKB)
Alt. Names/Synonyms: CD54; ICAM; ICAM-1; Icam1; Intercellular adhesion molecule 1
Gene Symbols: Icam1
Molecular weight: 60,142 Da
Basal Isoelectric point: 6.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene