TNF-R1 Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 6 F3|6 59.32 cM
Cellular Component:  axon; cell surface; cytosol; extracellular space; Golgi apparatus; Golgi membrane; integral component of membrane; membrane; membrane raft; mitochondrion; nucleus; plasma membrane; protein-containing complex; receptor complex; synapse
Molecular Function:  identical protein binding; protease binding; protein binding; protein-containing complex binding; tumor necrosis factor binding; tumor necrosis factor-activated receptor activity
Biological Process:  aortic valve development; apoptotic process; cell surface receptor signaling pathway; cytokine-mediated signaling pathway; defense response; defense response to bacterium; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of apoptotic process; negative regulation of cardiac muscle hypertrophy; negative regulation of extracellular matrix constituent secretion; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of interleukin-6 production; positive regulation of angiogenesis; positive regulation of apoptotic process involved in morphogenesis; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of neuron apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of STAT protein; prostaglandin metabolic process; protein heterooligomerization; protein localization to plasma membrane; pulmonary valve development; regulation of apoptotic process; regulation of establishment of endothelial barrier; signal transduction; tumor necrosis factor-mediated signaling pathway
Reference #:  P25118 (UniProtKB)
Alt. Names/Synonyms: CD120a; FPF; OTTMUSP00000028139; p55; p55-R; p60; TNF receptor alpha chain; TNF-alpha-R1; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-RI; TNFalpha-R1; TNFAR; Tnfr-1; Tnfr-2; TNFR-I; Tnfr1; TNFR60; TNFRI; TNFRp55; Tnfrsf1a; TNR1A; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily, member 1a; Tumor necrosis factor receptor type I
Gene Symbols: Tnfrsf1a
Molecular weight: 50,130 Da
Basal Isoelectric point: 7.36  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene