SLC18A3 Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. Peripheral and central cholinergic nervous systems. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 10q11.23
Cellular Component:  clathrin-coated vesicle membrane; clathrin-sculpted acetylcholine transport vesicle membrane; integral component of membrane; plasma membrane
Molecular Function:  acetylcholine transmembrane transporter activity
Biological Process:  acetate ester transport; ammonium transmembrane transport; drug transmembrane transport; membrane organization; neurotransmitter secretion; organic cation transport
Disease: Myasthenic Syndrome, Congenital, 21, Presynaptic
Reference #:  Q16572 (UniProtKB)
Alt. Names/Synonyms: MGC12716; SLC18A3; solute carrier family 18 (vesicular acetylcholine), member 3; Solute carrier family 18 member 3; solute carrier family 18, member 3; VACHT; Vesicular acetylcholine transporter
Gene Symbols: SLC18A3
Molecular weight: 56,903 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene