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BLM
ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction. Belongs to the helicase family. RecQ subfamily. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase |
| Chromosomal Location of mouse Ortholog: 7 D2|7 45.65 cM |
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Cellular Component:
chromosome; chromosome, telomeric region; cytoplasm; cytosol; lateral element; male germ cell nucleus; nuclear chromosome; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; pronucleus; protein-containing complex; RecQ family helicase-topoisomerase III complex; replication fork
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Molecular Function:
3'-5' DNA helicase activity; 8-hydroxy-2'-deoxyguanosine DNA binding; ATP binding; ATP-dependent activity, acting on DNA; bubble DNA binding; DNA binding; DNA helicase activity; DNA/DNA annealing activity; forked DNA-dependent helicase activity; four-way junction DNA binding; four-way junction helicase activity; G-quadruplex DNA binding; helicase activity; hydrolase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; identical protein binding; metal ion binding; molecular function activator activity; nucleic acid binding; nucleotide binding; p53 binding; protein binding; protein homodimerization activity; single-stranded DNA binding; telomeric D-loop binding; telomeric G-quadruplex DNA binding; Y-form DNA binding; zinc ion binding
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Biological Process:
alpha-beta T cell differentiation; alpha-beta T cell proliferation; cellular metabolic process; cellular response to camptothecin; cellular response to hydroxyurea; cellular response to ionizing radiation; cellular response to ketone; cellular response to organic cyclic compound; cellular response to organonitrogen compound; cellular response to xenobiotic stimulus; chromosome organization; DN4 thymocyte differentiation; DNA damage response; DNA double-strand break processing; DNA duplex unwinding; DNA recombination; DNA repair; DNA replication; DNA unwinding involved in DNA replication; double-strand break repair via homologous recombination; G-quadruplex DNA unwinding; immature T cell proliferation in thymus; mitotic G2 DNA damage checkpoint signaling; mitotic recombination; negative regulation of cell division; negative regulation of DNA recombination; negative regulation of mitotic recombination; negative regulation of thymocyte apoptotic process; positive regulation of alpha-beta T cell proliferation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair via homologous recombination; positive regulation of immature T cell proliferation in thymus; protein complex oligomerization; protein homooligomerization; regulation of binding; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of DNA-templated DNA replication; replication fork processing; replication-born double-strand break repair via sister chromatid exchange; resolution of recombination intermediates; response to X-ray; telomere maintenance; telomeric D-loop disassembly
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Reference #:
O88700
(UniProtKB)
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Alt. Names/Synonyms: Blm; Bloom syndrome homolog; Bloom syndrome homolog (human); Bloom syndrome protein homolog; Bloom syndrome, RecQ helicase-like; Bloom syndrome, RecQ like helicase; mBLM; RecQ helicase homolog; RecQ-like DNA helicase BLM
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Gene Symbols: Blm
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Molecular weight:
158,366 Da
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Basal Isoelectric point:
6.9
Predict pI for various phosphorylation states
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