GUCY1A1 a soluble guanylyl cyclase enzyme which interacts with a beta subunit to form the guanylate cyclase enzyme. Activated by nitric oxide. Detected in brain cortex and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc.
Chromosomal Location of rat Ortholog: 2q34
Cellular Component:  cytosol; GABA-ergic synapse; glutamatergic synapse; guanylate cyclase complex, soluble; protein-containing complex
Molecular Function:  GTP binding; guanylate cyclase activity; heme binding; ion binding; nucleotide binding; protein heterodimerization activity
Biological Process:  cGMP biosynthetic process; intracellular signal transduction; positive regulation of nitric oxide mediated signal transduction; regulation of blood pressure; relaxation of vascular smooth muscle; response to defense-related host nitric oxide production; response to herbicide; response to organic cyclic compound; retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Reference #:  P19686 (UniProtKB)
Alt. Names/Synonyms: GCS-alpha-1; GCS-alpha-3; GCYA1; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); Guanylate cyclase soluble subunit alpha-1; guanylate cyclase soluble subunit alpha-3; Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase); Guanylyl cyclase alpha 1 subunit; Gucy1a1; Gucy1a3; SGC; soluble guanylate cyclase large subunit
Gene Symbols: Gucy1a1
Molecular weight: 77,567 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene