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cytohesin 2
Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, ARF |
| Chromosomal Location of Human Ortholog: 7|7 B3 |
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Cellular Component:
bicellular tight junction; cell junction; cell projection; cytoplasm; extrinsic component of postsynaptic specialization membrane; membrane; plasma membrane; ruffle
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Molecular Function:
ARF guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; inositol 1,4,5 trisphosphate binding; lipid binding; protein binding
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Biological Process:
negative regulation of dendrite development; regulation of ARF protein signal transduction; regulation of cell adhesion
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Reference #:
P63034
(UniProtKB)
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Alt. Names/Synonyms: ARF nucleotide-binding site opener; ARNO; CLM; CLM2; CYH2; Cyth2; cytohesin 2; Cytohesin-2; mSec7-2; PH, SEC7 and coiled-coil domain-containing protein 2; pleckstrin homology, Sec7 and coiled-coil domains 2; Protein ARNO; Psc; Pscd2; SEC7 homolog B; Sec7b
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Gene Symbols: Cyth2
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Molecular weight:
46,585 Da
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Basal Isoelectric point:
5.49
Predict pI for various phosphorylation states
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