cytohesin 2 Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, ARF
Chromosomal Location of Human Ortholog: 7|7 B3
Cellular Component:  bicellular tight junction; cell junction; cell projection; cytoplasm; extrinsic component of postsynaptic specialization membrane; membrane; plasma membrane; ruffle
Molecular Function:  ARF guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; inositol 1,4,5 trisphosphate binding; lipid binding; protein binding
Biological Process:  negative regulation of dendrite development; regulation of ARF protein signal transduction; regulation of cell adhesion
Reference #:  P63034 (UniProtKB)
Alt. Names/Synonyms: ARF nucleotide-binding site opener; ARNO; CLM; CLM2; CYH2; Cyth2; cytohesin 2; Cytohesin-2; mSec7-2; PH, SEC7 and coiled-coil domain-containing protein 2; pleckstrin homology, Sec7 and coiled-coil domains 2; Protein ARNO; Psc; Pscd2; SEC7 homolog B; Sec7b
Gene Symbols: Cyth2
Molecular weight: 46,585 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
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cytohesin 2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene