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cytohesin 2
Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, ARF |
| Chromosomal Location of mouse Ortholog: 7|7 B3 |
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Cellular Component:
anchoring junction; bicellular tight junction; cell projection; cytoplasm; extrinsic component of postsynaptic specialization membrane; glutamatergic synapse; membrane; plasma membrane; postsynapse; ruffle
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Molecular Function:
guanyl-nucleotide exchange factor activity; inositol 1,4,5 trisphosphate binding; lipid binding; protein binding
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Biological Process:
negative regulation of dendrite development; regulation of ARF protein signal transduction; regulation of cell adhesion
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Reference #:
P63034
(UniProtKB)
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Alt. Names/Synonyms: ARF nucleotide-binding site opener; ARNO; CLM; CLM2; CYH2; Cyth2; cytohesin 2; Cytohesin-2; mSec7-2; PH, SEC7 and coiled-coil domain-containing protein 2; pleckstrin homology, Sec7 and coiled-coil domains 2; Protein ARNO; Psc; Pscd2; SEC7 homolog B; Sec7b
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Gene Symbols: Cyth2
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Molecular weight:
46,571 Da
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Basal Isoelectric point:
5.49
Predict pI for various phosphorylation states
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