ITGB1 a type 1 transmembrane protein of the integrin beta chain family. Heterodimerizes with multiple different alpha chains to form receptors for collagen, CSPG4, cytotactin, epiligrin, fibrinogen, fibronectin, fractalkine, IL1B, laminin, osteopontin, PLA2G2A, thrombospondin, VCAM1, and vitronectin. Essential for IL1B signaling. Recognizes the sequence R-G-D in a wide array of ligands. Involved in promoting endothelial cell motility and angiogenesis; osteoblast compaction; and up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. May participate in the adhesion, formation of invadopodia, matrix degradation processes, and promoting cell invasion. ITGA6:ITGB1 is present in oocytes and is involved in sperm-egg fusion. Acts as a coreceptor for human echoviruses 1 and 8, Cytomegalovirus, Epstein-Barr virus, human parvovirus B19, human rotavirus, and mammalian reovirus. In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein, seeming to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin beta chain family. 5 alternatively spliced human isoforms have been reported. Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle). Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 19q12
Cellular Component:  acrosomal vesicle; adherens junction; basement membrane; cell surface; cell-cell junction; cytoplasm; cytoplasmic vesicle; dendritic spine; external side of plasma membrane; filopodium; focal adhesion; glial cell projection; glutamatergic synapse; hemidesmosome; integral component of postsynaptic membrane; integral component of synaptic membrane; integrin alpha1-beta1 complex; integrin alpha10-beta1 complex; integrin alpha11-beta1 complex; integrin alpha2-beta1 complex; integrin alpha3-beta1 complex; integrin alpha7-beta1 complex; integrin alpha9-beta1 complex; integrin complex; intercalated disc; invadopodium membrane; lamellipodium; melanosome; membrane; membrane raft; myelin sheath abaxonal region; neuromuscular junction; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; receptor complex; recycling endosome; ruffle membrane; sarcolemma; Schaffer collateral - CA1 synapse; synapse; synaptic membrane
Molecular Function:  actin binding; alpha-actinin binding; C-X3-C chemokine binding; cell adhesion molecule binding; collagen binding; collagen binding involved in cell-matrix adhesion; fibronectin binding; integrin binding; kinase binding; laminin binding; metal ion binding; protease binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein kinase binding; protein-containing complex binding; signaling receptor activity; signaling receptor binding
Biological Process:  axon extension; basement membrane organization; bicellular tight junction assembly; calcium-independent cell-matrix adhesion; cardiac muscle cell differentiation; cardiac muscle tissue development; cell adhesion; cell adhesion mediated by integrin; cell fate specification; cell migration; cell migration involved in sprouting angiogenesis; cell projection organization; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; cellular response to ionizing radiation; cellular response to low-density lipoprotein particle stimulus; cellular response to mechanical stimulus; cellular response to vitamin D; dendrite morphogenesis; establishment of Sertoli cell barrier; formation of radial glial scaffolds; G1/S transition of mitotic cell cycle; germ cell migration; heterotypic cell-cell adhesion; in utero embryonic development; integrin-mediated signaling pathway; lamellipodium assembly; leukocyte cell-cell adhesion; leukocyte tethering or rolling; maternal process involved in female pregnancy; mesodermal cell differentiation; modulation of chemical synaptic transmission; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cell differentiation; negative regulation of cell projection organization; negative regulation of cell proliferation; negative regulation of neuron differentiation; negative regulation of Rho protein signal transduction; neuron projection development; phagocytosis; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-substrate adhesion; positive regulation of endocytosis; positive regulation of GTPase activity; positive regulation of neuron differentiation; positive regulation of neuron projection development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein localization to plasma membrane; positive regulation of signaling receptor activity; protein transport within lipid bilayer; receptor internalization; regulation of cell cycle; regulation of collagen catabolic process; regulation of G protein-coupled receptor signaling pathway; response to activity; response to drug; response to gonadotropin; response to nutrient levels; response to transforming growth factor beta; sarcomere organization; synaptic membrane adhesion to extracellular matrix; tissue homeostasis; visual learning
Reference #:  P49134 (UniProtKB)
Alt. Names/Synonyms: Beta OL; Beta oligodendroglia; Fibronectin receptor subunit beta; integrin beta 1 (fibronectin receptor beta); Integrin beta-1; integrin VLA-4 subunit beta; integrin, beta 1; ITB1; Itgb1; VLA-4 subunit beta
Gene Symbols: Itgb1
Molecular weight: 88,495 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ITGB1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene