CDK9 a protein kinase of the CDK family. Forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. Together with cyclin-T, it is a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. Transcriptional elongation factor and cofactor for HIV Tat protein; RNAi blocks HIV replication, and inhibitors also block varicella zoster replication. Mediates signals leading to cardiac hypertrophy. Inhibitor: Flavopiridol. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK9 subfamily; CDK9 subfamily; CMGC group; Cell cycle regulation; EC; EC; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 2|2 B
Cellular Component:  chromosome; cyclin-dependent protein kinase holoenzyme complex; cyclin/CDK positive transcription elongation factor complex; cytoplasm; cytoplasmic ribonucleoprotein granule; nuclear chromatin; nucleoplasm; nucleus; PML body; transcription elongation factor complex
Molecular Function:  7SK snRNA binding; ATP binding; chromatin binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; DNA binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; RNA polymerase II proximal promoter sequence-specific DNA binding; snRNA binding; transcription coactivator binding; transcription factor binding; transcription regulatory region DNA binding; transferase activity
Biological Process:  cellular response to cytokine stimulus; cellular response to DNA damage stimulus; DNA repair; negative regulation of cell cycle arrest; negative regulation of mRNA polyadenylation; phosphorylation; phosphorylation of RNA polymerase II C-terminal domain; positive regulation of cardiac muscle hypertrophy; positive regulation of histone H2B ubiquitination; positive regulation of histone phosphorylation; positive regulation of mRNA 3'-UTR binding; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation from RNA polymerase II promoter; protein phosphorylation; regulation of DNA repair; regulation of histone modification; regulation of muscle cell differentiation; replication fork processing; transcription elongation from RNA polymerase II promoter
Reference #:  Q99J95 (UniProtKB)
Alt. Names/Synonyms: Cdk9; Cell division protein kinase 9; Cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); OTTMUSP00000013406; PITALRE; PTEFB
Gene Symbols: Cdk9
Molecular weight: 42,762 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA