FPR1 High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. Belongs to the G-protein coupled receptor 1 family. Neutrophils. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 17 A3.2|17 10.63 cM
Cellular Component:  cytoplasm; integral component of membrane; membrane; plasma membrane
Molecular Function:  G protein-coupled receptor activity; G protein-coupled receptor binding; N-formyl peptide receptor activity; RAGE receptor binding; scavenger receptor binding
Biological Process:  chemotaxis; complement receptor mediated signaling pathway; G protein-coupled receptor signaling pathway; inflammatory response; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; signal transduction
Reference #:  P33766 (UniProtKB)
Alt. Names/Synonyms: fMet-Leu-Phe receptor; fMLF; fMLF-R; fMLP receptor; formyl peptide receptor 1; FPR; Fpr1; lipoxin A4 receptor; LXA4R; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor; OTTMUSP00000024381
Gene Symbols: Fpr1
Molecular weight: 40,327 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene