|
PTPRE
Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function. Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake. Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells). 3 alternative promoter and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine |
| Chromosomal Location of human Ortholog: 10q26.2 |
|
Cellular Component:
cytoplasm; nucleus; plasma membrane
|
|
Molecular Function:
protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity
|
|
Biological Process:
negative regulation of insulin receptor signaling pathway; protein dephosphorylation
|
|
Reference #:
P23469
(UniProtKB)
|
|
Alt. Names/Synonyms: DKFZp313F1310; FLJ57799; FLJ58245; HPTPE; protein tyrosine phosphatase epsilon; protein tyrosine phosphatase receptor type E; protein tyrosine phosphatase, receptor type, E; protein tyrosine phosphatase, receptor type, epsilon polypeptide; Protein-tyrosine phosphatase epsilon; PTPE; PTPRE; R-PTP-epsilon; Receptor-type tyrosine-protein phosphatase epsilon
|
|
Gene Symbols: PTPRE
|
|
Molecular weight:
80,642 Da
|
|
Basal Isoelectric point:
6.57
Predict pI for various phosphorylation states
|
