PTS Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. Belongs to the PTPS family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; EC; Lyase; Mitochondrial
Chromosomal Location of Human Ortholog: 9|9 A5.3
Cellular Component:  cytoplasm; mitochondrion
Molecular Function:  6-pyruvoyltetrahydropterin synthase activity; identical protein binding; lyase activity; metal ion binding; protein binding; protein homodimerization activity
Biological Process:  tetrahydrobiopterin biosynthetic process
Reference #:  Q9R1Z7 (UniProtKB)
Alt. Names/Synonyms: 6-pyruvoyl tetrahydrobiopterin synthase; 6-pyruvoyl-tetrahydropterin synthase; PTP synthase; PTPS; Pts
Gene Symbols: Pts
Molecular weight: 16,188 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene