Kir6.2 This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p15.1
Cellular Component:  acrosomal vesicle; axolemma; cell body fiber; cytosol; endoplasmic reticulum; endosome; integral component of plasma membrane; intercalated disc; inward rectifying potassium channel; mitochondrion; myelin sheath; neuronal cell body; nuclear envelope; plasma membrane; T-tubule
Molecular Function:  ankyrin binding; ATP binding; ATP-activated inward rectifier potassium channel activity; heat shock protein binding; ion channel binding; potassium ion binding; protein binding; protein C-terminus binding; voltage-gated potassium channel activity
Biological Process:  cellular response to glucose stimulus; cellular response to nicotine; cellular response to tumor necrosis factor; glucose metabolic process; negative regulation of insulin secretion; nervous system process; positive regulation of cation channel activity; positive regulation of protein localization to plasma membrane; potassium ion import across plasma membrane; potassium ion transmembrane transport; regulation of cardiac conduction; regulation of insulin secretion; regulation of membrane potential; response to ATP; response to drug; response to estradiol; response to ischemia; response to testosterone; transmembrane transport
Disease: Diabetes Mellitus, Noninsulin-dependent; Diabetes Mellitus, Permanent Neonatal; Diabetes Mellitus, Transient Neonatal, 3; Hyperinsulinemic Hypoglycemia, Familial, 2; Maturity-onset Diabetes Of The Young, Type 13
Reference #:  Q14654 (UniProtKB)
Alt. Names/Synonyms: ATP-sensitive inward rectifier potassium channel 11; beta-cell inward rectifier subunit; BIR; HHF2; IKATP; Inward rectifier K(+) channel Kir6.2; inwardly rectifying potassium channel KIR6.2; IRK11; KCNJ11; KIR6.2; MGC133230; PHHI; potassium channel inwardly rectifing subfamily J member 11; Potassium channel, inwardly rectifying subfamily J member 11; potassium inwardly-rectifying channel J11; potassium inwardly-rectifying channel, subfamily J, member 11; TNDM3
Gene Symbols: KCNJ11
Molecular weight: 43,541 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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