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Kir6.2
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 11p15.1 |
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Cellular Component:
inward rectifying potassium channel; plasma membrane; T-tubule
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Molecular Function:
ankyrin binding; ATP binding; ATP-activated inward rectifier potassium channel activity; ATPase-coupled cation transmembrane transporter activity; inward rectifier potassium channel activity; potassium ion binding; protein binding; transmembrane transporter binding; voltage-gated ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated potassium channel activity
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Biological Process:
glucose metabolic process; inorganic cation transmembrane transport; negative regulation of insulin secretion; nervous system process; positive regulation of insulin secretion involved in cellular response to glucose stimulus; potassium ion import across plasma membrane; potassium ion transmembrane transport; regulation of insulin secretion; regulation of ion transmembrane transport; regulation of membrane potential; regulation of presynaptic membrane potential; response to ATP; response to xenobiotic stimulus
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Disease: Diabetes Mellitus, Noninsulin-dependent; Diabetes Mellitus, Permanent Neonatal 2; Diabetes Mellitus, Transient Neonatal, 3; Hyperinsulinemic Hypoglycemia, Familial, 2; Maturity-onset Diabetes Of The Young, Type 13
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Reference #:
Q14654
(UniProtKB)
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Alt. Names/Synonyms: ATP-sensitive inward rectifier potassium channel 11; beta-cell inward rectifier subunit; BIR; HHF2; IKATP; Inward rectifier K(+) channel Kir6.2; inwardly rectifing potassium channel subfamily J member 11; inwardly rectifying potassium channel KIR6.2; inwardly-rectifying potassium channel subfamily J member 11; IRK11; KCJ11; KCNJ11; KIR6.2; MGC133230; MODY13; PHHI; PNDM2; potassium channel inwardly rectifing subfamily J member 11; Potassium channel, inwardly rectifying subfamily J member 11; potassium inwardly rectifying channel subfamily J member 11; potassium inwardly-rectifying channel J11; potassium inwardly-rectifying channel, subfamily J, member 11; potassium voltage-gated channel subfamily J member 11; TNDM3
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Gene Symbols: KCNJ11
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Molecular weight:
43,526 Da
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Basal Isoelectric point:
8.63
Predict pI for various phosphorylation states
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