HSP20 Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. Belongs to the small heat shock protein (HSP20) family. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of human Ortholog: 19q13.12
Cellular Component:  cytoplasm; extracellular region; nucleus
Molecular Function:  chaperone binding; protein binding; protein homodimerization activity; structural constituent of eye lens; unfolded protein binding
Biological Process:  chaperone-mediated protein folding; negative regulation of cardiac muscle cell apoptotic process; positive regulation of angiogenesis; regulation of muscle contraction
Reference #:  O14558 (UniProtKB)
Alt. Names/Synonyms: epididymis luminal protein 55; epididymis secretory sperm binding protein; FLJ32389; Heat shock 20 kDa-like protein p20; Heat shock protein beta-6; heat shock protein family B (small) member 6; heat shock protein family B (small) member B6; heat shock protein, alpha-crystallin-related, B6; HEL55; Hsp20; HSPB6; PPP1R91; protein phosphatase 1, regulatory subunit 91
Gene Symbols: HSPB6
Molecular weight: 17,136 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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HSP20

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene