NCX1 Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. Detected primarily in heart and at lower levels in brain (PubMed:1374913). Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family
Cellular Component:  integral component of plasma membrane; intrinsic component of plasma membrane; nucleoplasm; postsynapse; sarcolemma
Molecular Function:  ankyrin binding; calcium ion binding; calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration; calcium:sodium antiporter activity; calmodulin binding
Biological Process:  calcium ion import; calcium ion transmembrane transport; cell communication; cellular sodium ion homeostasis; positive regulation of bone mineralization; positive regulation of the force of heart contraction; regulation of postsynaptic cytosolic calcium ion concentration; response to muscle stretch; sodium ion import across plasma membrane; sodium ion transmembrane transport
Reference #:  P23685 (UniProtKB)
Alt. Names/Synonyms: Na(+)/Ca(2+)-exchange protein 1; Na/Ca-exchange protein 1; NAC1; NCX1; SLC8A1; Sodium/calcium exchanger 1; Solute carrier family 8 member 1
Gene Symbols: SLC8A1
Molecular weight: 108,004 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein