NCX1
Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. Detected primarily in heart and at lower levels in brain (PubMed:1374913). Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family
Cellular Component: nucleoplasm; plasma membrane
Molecular Function: ankyrin binding; calcium ion binding; calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration; calcium:sodium antiporter activity; calmodulin binding
Biological Process: calcium ion import; calcium ion transmembrane transport; cell communication; intracellular sodium ion homeostasis; positive regulation of bone mineralization; positive regulation of the force of heart contraction; regulation of postsynaptic cytosolic calcium ion concentration; response to muscle stretch; sodium ion import across plasma membrane; sodium ion transmembrane transport
Alt. Names/Synonyms: Na(+)/Ca(2+)-exchange protein 1; Na/Ca-exchange protein 1; NAC1; NCX1; SLC8A1; Sodium/calcium exchanger 1; Solute carrier family 8 member 1
