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calponin 1
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. Smooth muscle, and tissues containing significant amounts of smooth muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding |
| Chromosomal Location of mouse Ortholog: 9|9 A3 |
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Cellular Component:
actin cytoskeleton; cytoskeleton
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Molecular Function:
actin binding; actin filament binding; calmodulin binding
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Biological Process:
actin filament organization; actomyosin structure organization; negative regulation of vascular associated smooth muscle cell proliferation
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Reference #:
Q08091
(UniProtKB)
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Alt. Names/Synonyms: Basic calponin; calponin 1; Calponin H1, smooth muscle; Calponin-1; CN; Cnn1; CnnI
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Gene Symbols: Cnn1
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Molecular weight:
33,356 Da
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Basal Isoelectric point:
9.05
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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