PKAR1A Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Belongs to the cAMP-dependent kinase regulatory chain family. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Cellular Component:  axoneme; cAMP-dependent protein kinase complex; cytoplasm; glutamatergic synapse; immunological synapse; neuromuscular junction; nucleotide-activated protein kinase complex; plasma membrane raft
Molecular Function:  cAMP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; identical protein binding; protein binding; protein domain specific binding; protein kinase A catalytic subunit binding; ubiquitin protein ligase binding
Biological Process:  cardiac muscle cell proliferation; mesoderm formation; negative regulation of activated T cell proliferation; negative regulation of cAMP-dependent protein kinase activity; sarcomere organization
Reference #:  P00514 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase type I-alpha regulatory chain; cAMP-dependent protein kinase type I-alpha regulatory subunit; KAP0; PKA R1-alpha; PKAR1A; PRKAR1A
Gene Symbols: PRKAR1A
Molecular weight: 42,893 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein