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GBPI-1
Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family. Detected in colon, intestine, kidney and brain cortex. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor; Protein phosphatase, regulatory subunit |
| Chromosomal Location of rat Ortholog: 3q35 |
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Cellular Component:
cytoplasm; membrane
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Molecular Function:
protein serine/threonine phosphatase inhibitor activity
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Biological Process:
negative regulation of protein serine/threonine phosphatase activity; positive regulation of protein serine/threonine phosphatase activity; regulation of phosphorylation
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Reference #:
Q8K3F4
(UniProtKB)
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Alt. Names/Synonyms: Gastrointestinal and brain-specific PP1-inhibitory protein 1; gastrointestinal- and brain-specific PKC-activated PP1 inhibitor; Gbpi; GBPI-1; PP14D; Ppp1r14d; Protein phosphatase 1 regulatory subunit 14D; protein phosphatase 1, regulatory (inhibitor) subunit 14D
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Gene Symbols: Ppp1r14d
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Molecular weight:
16,867 Da
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Basal Isoelectric point:
6.75
Predict pI for various phosphorylation states
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